Synthesis of saracatinib

Hai Feng Shang; Yu Bin Wang; Da Min Zhao; Qi Zhang; Jin Xiong She

Synthesis of saracatinib

Hai Feng Shang, Yu Bin Wang, Da Min Zhao, Qi Zhang, Jin Xiong She

食品与轻工学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by ¹H-NMR and MS. This synthetic method was suitable for large-scale production.

源语言	英语
页（从-至）	2363-2366
页数	4
期刊	Chinese Journal of New Drugs
卷	20
期	23
出版状态	已出版 - 15 12月 2011

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@article{84b121a9c6a647f48417d6966bce6c50,

title = "Synthesis of saracatinib",

abstract = "To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.",

keywords = "Saracatinib, Synthesis, Tyrosine kinase inhibitor",

author = "Shang, {Hai Feng} and Wang, {Yu Bin} and Zhao, {Da Min} and Qi Zhang and She, {Jin Xiong}",

year = "2011",

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day = "15",

language = "英语",

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pages = "2363--2366",

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TY - JOUR

T1 - Synthesis of saracatinib

AU - Shang, Hai Feng

AU - Wang, Yu Bin

AU - Zhao, Da Min

AU - Zhang, Qi

AU - She, Jin Xiong

PY - 2011/12/15

Y1 - 2011/12/15

N2 - To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.

AB - To synthesize the Src kinase inhibitor saracatinib, and optimize the synthetic process. Medthods: Saracatinib was synthesized from 2, 4, 6-trifluorobenzonitrile through procedures of ammonolysis, hydrolysis, cyclization, and substitution. Results and Conclusion: Saracatinib was synthesized with a total yield of 24.54%, and was verified by 1H-NMR and MS. This synthetic method was suitable for large-scale production.

KW - Saracatinib

KW - Synthesis

KW - Tyrosine kinase inhibitor

UR - http://www.scopus.com/inward/record.url?scp=84859491993&partnerID=8YFLogxK

M3 - 文章

AN - SCOPUS:84859491993

SN - 1003-3734

VL - 20

SP - 2363

EP - 2366

JO - Chinese Journal of New Drugs

JF - Chinese Journal of New Drugs

IS - 23

ER -

Synthesis of saracatinib

摘要

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