A hydroxyphenylquinazolinone-based fluorescent probe for turn-on detection of cysteine with a large Stokes shift and its application in living cells

Huace Sheng, Yonghong Hu, Yi Zhou, Shimin Fan, Yang Cao, Xinxin Zhao, Wenge Yang

科研成果: 期刊稿件文章同行评审

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摘要

A hydroxyphenylquinazolinone-based fluorescent probe DAP-1 with a large Stokes shift (162 nm) was firstly developed for detection of cysteine. The probe DAP-1 with two acrylate as highly Cys-selective sites was designed based on the combination of excited state intramolecular proton transfer (ESIPT) and aggregation-induced emission (AIE) mechanism. Upon the treatment with cysteine, DAP-1 displayed a strong fluorescence enhancement (65-fold). The limit of detection obtained from fluorescent titration was as low as 0.03 μM. DAP-1 could detect cysteine with high selectivity and sensitivity. Significantly, DAP-1 could be used to detect cysteine in living cells.

源语言英语
页(从-至)750-757
页数8
期刊Journal of Photochemistry and Photobiology A: Chemistry
364
DOI
出版状态已出版 - 1 9月 2018

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